Family

• Rubiaceae

Constituents

• Alkaloids (mitrafilin, isopterpodin and pteropodin)
• Glycosidic quinovic acid
• Flavonoids
• Triterpenes
• procyanidins
• Phytosterols

Parts used

• Bark
• Root
• Leaf

Properties

• Anti-inflammatory
• Immunomodulator
• Antioxidant
• Antitumor
• Antihypertensive

Indications

• Arthritis
• Rheumatoid arthritis 
• Arthrosis / osteoarthritis
• Type 1 diabetes (prevents progression)
• Hypertension

Side effects

In high doses, cat's claw can cause intestinal problems such as diarrhea or constipation, depending on the sensitivity of the person.

It can also cause fatigue, fever, pancreatic symptoms, and optic nerve changes.

There are studies that indicate antiplatelet effects.

Contraindications

This plant should not be used by pregnant women, nursing mothers, children under 3 years old, people who have had an organ transplant or who intend to have an organ transplant.

It should not be used by women who are trying to become pregnant, there is a study that suggests a possible contraceptive effect.

People who have a history of bleeding, clotting disorders, or who take anticoagulants, should take cat's claw with caution, as there is antiplatelet potential.

Interactions

May interact with laxatives, causing cramps and diarrhea.

Possible interaction with antiretroviral protease inhibitors (such as atazanavir, ritonavir, and saquinavir), cyclosporine, calcium channel blockers, reverse transcriptase inhibitors, and other drugs influenced by the CYP3A4 enzyme.

Forms of use

• Capsule or tablet
• Infusion
• Decoction
• Tincture